INTRACELLULAR DISPOSITION OF CHITOSAN NANOPARTICLES IN MACROPHAGES: INTRACELLULAR UPTAKE, EXOCYTOSIS, AND INTERCELLULAR TRANSPORT

Intracellular disposition of chitosan nanoparticles in macrophages: intracellular uptake, exocytosis, and intercellular transport

Li Qun Jiang,1 Skincare, Beauty, Perfume and Cologne Products Ting Yu Wang,1 Thomas J Webster,2 Hua-Jian Duan,1 Jing Ying Qiu,1 Zi Ming Zhao,1 Xiao Xing Yin,1,* Chun Li Zheng3,* 1Jiangsu Key Laboratory of New Drug Research and Clinical Pharmacy, School of Pharmacy, Xuzhou Medical University, Xuzhou, People’s Republic of China; 2Department of

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Case report: Patients with positive HER-2 amplification locally advanced gastroesophageal junction cancer achieved pathologic complete response with the addition of pembrolizumab to chemotherapy plus trastuzumab as neoadjuvant therapy

BackgroundHuman epidermal growth factor receptor 2(HER-2) is the most prominent therapeutic target for gastric (G)/gastroesophageal junction (GEJ) cancer.Guidelines recommend its use for treating G/GEJ cancers.However, targeted therapy did not significantly improve survival outcomes compared to those with neoadjuvant therapy.The KEYNOTE-811 trial r

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